Il Farmaco

Synthesis and biological evaluation of enantiomerically pure pyrrolyl-oxazolidinones as a new class of potent and selective monoamine oxidase type A inhibitors

…, M Artico, M Esposito, R Ragno, G Sbardella, S Massa

Index: Mai; Artico, Marino; Esposito; Ragno; Sbardella; Massa Farmaco, 2003 , vol. 58, # 3 p. 231 - 241

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Citation Number: 27

Abstract

Due to the key role played by monoamine oxidases (MAOs) in the metabolism of neurotransmitters, MAO inhibitors (MAOIs) represent an useful tool for the treatment of several neurological diseases. Among selective MAOIs, MAO-A inhibitors (eg clorgyline) are used as antidepressant and antianxiety drugs and are claimed to protect neuronal cells against apoptosis, and selective MAO-B inhibitors (eg l-deprenyl) can be used in the ...