A Facile Two-Step Synthesis of 3-Fluoro-6-methoxyquinoline

B Li, Z Zhang, M Mangano

Index: Li, Bryan; Zhang, Zhijun; Mangano, Michael Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1273 - 1275

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Citation Number: 2

Abstract

A facile two-step synthesis of 3-fluoro-6-methoxyquinoline is described. p-Anisidine was heated at reflux with 2-fluoromalonic acid in the presence of phosphorus oxychloride to produce 2, 4-dichloro-3-fluoro-6-methoxyquinoline. This was followed by hydrogenolysis to produce 3-fluoro-6-methoxyquinoline.