Pyrazolopyrimidine nucleosides. 13. Synthesis of the novel C-nucleoside 5-amino-3-(. beta.-D-ribofuranosyl) pyrazolo [4, 3-d] pyrimidin-7-one, a guanosine analog …

AF Lewis, LB Townsend

Index: Lewis; Townsend Journal of the American Chemical Society, 1982 , vol. 104, # 4 p. 1073 - 1077

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Citation Number: 28

Abstract

B] has been prepared from the adenosine-type C-nucleoside antibiotic formycin. The synthetic route has used an initial ring opening followed by a series of chemical transformations and subsequent ring closure to afford 5-aminoformycin B. This synthetic route was also used to prepare the heterocyclic aglycon, 5-aminopyrazolo [4, 3-d] pyrimidin- 7-one, of the guanosine derivative.