Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1–E2–Origin DNA complex

…, J Naud, B Hache, JA O'Meara, MG Cordingley…

Index: Yoakim, Christiane; Ogilvie, William W.; Goudreau, Nathalie; Naud, Julie; Hache, Bruno; O'Meara, Jeff A.; Cordingley, Michael G.; Archambault, Jacques; White, Peter W. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 15 p. 2539 - 2541

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Citation Number: 48

Abstract

Confirmation of our initial hit structure as well as the relative stereochemistry of the substituent on the furan ring was accomplished via an independent synthesis. Synthesis of 1, Scheme 1 and Scheme 2 was achieved based on a literature procedure 10 and is outlined in Scheme 1. Commercially available indan-1,3-dione was condensed with p-chlorobenzaldehyde in the presence of a catalytic amount of piperidine to give the corresponding benzylidene. Base- ...