Hydroxamic acid analogues are important targets for the medicinal chemists because of the intrinsic chelating interactions of this functional group with Zn++ at the active site of metalloprotiens [1, 2]. Also hydroxamic acids are important in many chemotherapeutic agents such as the succinate-based matrix metalloprotienases (MMP) inhibitors [3], the class I/II histone deacetylase (HDAC) inhibitors [4] and iron-containing antibiotics [5]. Literature ...
