Abstract Four alkyl g-ketohexanoates (3a-3d) have been prepared from succinic anhydride employing a three step reaction strategy. In the first step using p-toluene sulfonic acid as catalyst, the ring of succinic anhydride was opened with isopropyl, isobutyl, isopentyl and benzyl alcohols, respectively to form alkyl hydrogen succinates (1a-1d). In the 2nd step these alkyl hydrogen succinates on treatment with SOCl2 yielded 4-alkoxy-4-ketobutanoyl ...
[Vasta, James D.; Higgin, Joshua J.; Kersteen, Elizabeth A.; Raines, Ronald T. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 12 p. 3597 - 3601]
[Vasta, James D.; Higgin, Joshua J.; Kersteen, Elizabeth A.; Raines, Ronald T. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 12 p. 3597 - 3601]
