Cyano-functionalized allylic phosphine substrates containing the ortho-metalated (R)-(1- (dimethylamino) ethyl) naphthalene as the chiral auxiliary were synthesized from bromoacetaldehyde dimethylacetal via a one-pot process. The diastereoselective hydrophosphination reactions of the cis-and trans-allylic phosphine substrates gave the cyano-functionalized chiral 1, 2-bis (diphenylphosphino) ethane products with high yield ...
