Isolation and identification of α-CEHC sulfate in rat urine and an improved method for the determination of conjugated α-CEHC

…, CC Cheng, YS Wein, YH Kuo, C Huang

Index: Li, Yi-Jen; Luo, Sheng-Ching; Lee, Yi-Jing; Lin, Fu-Jung; Cheng, Chi-Cheng; Wein, Yung-Shung; Kuo, Yueh-Hsiung; Huang, Ching-Jang Journal of Agricultural and Food Chemistry, 2008 , vol. 56, # 23 p. 11105 - 11113

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Citation Number: 13

Abstract

2, 5, 7, 8-Tetramethyl-2-(2′-carboxyethyl)-6-hydroxychroman (α-CEHC), the water-soluble metabolite of α-tocopherol (α-TOH) with a shortened side chain but an intact hydroxychroman structure, has been identified in human urine and are thought to be produced in significant amount at excess intake of α-TOH. In previous studies, CEHCs in biological specimens were measured by HPLC, GC− MS or LC− MS, preceded by a ...