Tetrahedron Letters

A simple and efficient synthesis of trihalomethyl and dihalonitromethyl aryl sulfones

KM Borys, MD Korzyński, Z Ochal

Index: Borys, Krzysztof M.; Korzynski, MacIej D.; Ochal, Zbigniew Tetrahedron Letters, 2012 , vol. 53, # 48 p. 6606 - 6610,5

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Citation Number: 16

Abstract

A method for the preparation of aryl trihalomethyl sulfones—active biocidal agents—with identical or different halogens is presented. The synthesis is based on the reaction of aryl methyl, aryl halomethyl, or aryl nitromethyl sulfones with sodium hypohalite. The method is simple in implementation, does not necessarily require the use of organic solvents, and selectively affords the products in good to excellent yields. Notably, it allows the ...