Summary: Functionalized oxazoles and bis-oxazoles are obtained by side-chain oxidation of &hydroxy amides with the Dess-Martin periodinane, followed by cyclodehydra- tion with triphenylphosphineliodine in the presence of triethylamine. ... As a part of our efforts toward the total synthesis of the antiviral natural products tantazoles (1) and thiangazole (2),l we have investigated several protocols for the oxidative conversion of cy-amino-8-hydroxy acid derivatives into the corresponding ...
