e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death
…, ADT de Oliveira, PAT de Moraes Gomes…
Index: Magalhaes Moreira, Diogo Rodrigo; De Oliveira, Ana Daura Travassos; Teixeira De Moraes Gomes, Paulo Andre; De Simone, Carlos Alberto; Villela, Filipe Silva; Ferreira, Rafaela Salgado; Da Silva, Aline Caroline; Dos Santos, Thiago Andre Ramos; Brelaz De Castro, Maria Carolina Accioly; Pereira, Valeria Rego Alves; Leite, Ana Cristina Lima European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 467 - 478
Abstract Chagas disease, caused by Trypanosoma cruzi, is a life-threatening infection leading to approximately 12,000 deaths per year. T. cruzi is susceptible to thiosemicarbazones, making this class of compounds appealing for drug development. Previously, the homologation of aryl thiosemicarbazones resulted in an increase in anti-T. cruzi activity in comparison to aryl thiosemicarbazones without a spacer group. Here, we ...
