Tetrahedron Letters

One-step synthesis of 4 (3H)-quinazolinones

MJ Deetz, JP Malerich, AM Beatty, BD Smith

Index: Deetz, Martin J.; Malerich, Jeremiah P.; Beatty, Alicia M.; Smith, Bradley D. Tetrahedron Letters, 2001 , vol. 42, # 10 p. 1851 - 1854

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Citation Number: 42

Abstract

2-Fluoro substituted benzoyl chlorides undergo cyclocondensation with 2-amino-N- heterocycles to form 4 (3H)-quinazolinones. The reaction proceeds in moderate yields with different combinations of benzoyl chlorides and 2-amino-N-heterocycles. The products generally precipitate from the reaction mixture and require no further purification. Two tetrafluoro quinazolinones were found to be moderately active against a number of tumor ...