A selective metal–halogen exchange/electrophilic quench protocol on 4, 4′- dibromobiphenyl 4 that proceeds under non-cryogenic conditions is reported. This method provides an economic alternative to traditional transition-metal catalyzed cross-coupling chemistry to prepare various biaryls 7a–g. This novel route to functionalized biaryls was used as the basis for the kg-scale preparation of a biphenyl ketone 1, a key intermediate ...
![[1,1'-Biphenyl]-4-methanol,4'-bromo-a-phenyl- Structure](https://image.chemsrc.com/caspic/215/63242-23-9.png)
![2,2,2-trifluoro-1-[4-(4-methylsulfanylphenyl)phenyl]ethanone Structure](https://image.chemsrc.com/caspic/230/893407-15-3.png)
![2,2,2-trifluoro-1-[4'-(methylsulphonyl)biphenyl-4-yl]ethane-1,1-diol Structure](https://image.chemsrc.com/caspic/074/875272-88-1.png)
