Advanced Synthesis & Catalysis

Regioselective Synthesis of Indoles via Rhodium??Catalyzed C H Activation Directed by an In??Situ Generated Redox??Neutral Group

K Muralirajan, CH Cheng

Index: Muralirajan, Krishnamoorthy; Cheng, Chien-Hong Advanced Synthesis and Catalysis, 2014 , vol. 356, # 7 p. 1571 - 1576

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Citation Number: 45

Abstract

Abstract: A regioselective synthesis of indoles from arylhydrazine hydrochlorides with alkynes and diethyl ketone catalyzed by a rhodium complex is described. A possible mechanism involving an in-situ generated oxidizing directing group ÀNÀN= CR1R2 assisted ortho-CÀH activation and reductive elimination are proposed. The catalytic reaction is highly compatible with a wide range of functional arylhydrazines and alkynes. The reaction ...

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