Sulfur and selenium derivatives of quinazoline and pyrido [2, 3-d] pyrimidine: synthesis and study of their potential cytotoxic activity in vitro

E Moreno, D Plano, I Lamberto, M Font, I Encío…

Index: Moreno, Esther; Plano, Daniel; Lamberto, Iranzu; Font, Maria; Encio, Ignacio; Palop, Juan Antonio; Sanmartin, Carmen European Journal of Medicinal Chemistry, 2012 , vol. 47, # 1 p. 283 - 298

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Citation Number: 45

Abstract

The synthesis, cytotoxic activities and selectivities of 35 derivatives related to quinazoline and pyrido [2, 3-d] pyrimidine are described. The synthesized compounds were screened in vitro against four tumoral cell lines–leukemia (CCRF-CEM), colon (HT-29), lung (HTB-54) and breast (MCF-7)–and two cell lines derived from non-malignant cell lines, one mammary (184B5) and one from bronchial epithelium (BEAS-2B). MCF-7 and HTB-54 were the most ...