Potential antitumor agents. 29. Quantitative structure-activity relationships for the antileukemic bisquaternary ammonium heterocycles

WA Denny, GJ Atwell, BC Baguley…

Index: Denny,W.A. et al. Journal of Medicinal Chemistry, 1979 , vol. 22, p. 134 - 150

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Citation Number: 73

Abstract

Quantitative relationships between physicochemical drug properties and antileukemic (L1210) efficacy have been examined for a series of bisquaternary ammonium heterocycles employing multiple variable regression analysis. Three measures of biologic response were examined: ILS,,, the percentage increase in mean life span of leukemic animals at the LDlo dose; D,,, the drug dose necessary to provide 40% increase in life span; and CI (= LD, o/ ...

Combinatorial knoevenagel reactions

[Lokhande, S. B.; Rangnekar, D. W. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 485 - 488]

Comparison of 1, 4-distyrylfluorene and 1, 4-distyrylbenzene...

[Laughlin, Brynna J.; Duniho, Tyler L.; El Homsi, Samantha J.; Levy, Benjamin E.; Deligonul, Nihal; Gaffen, Joshua R.; Protasiewicz, John D.; Tennyson, Andrew G.; Smith, Rhett C. Organic and Biomolecular Chemistry, 2013 , vol. 11, # 33 p. 5425 - 5434]

Wittig reactions in water media employing stabilized ylides ...

[Schiemenz,G.P.; Thobe,J. Chemische Berichte, 1966 , vol. 99, p. 2663 - 2668]