Bioorganic & medicinal chemistry letters

Synthesis and evaluation of novel 2, 3, 5-triaryl-4H, 2, 3, 3a, 5, 6, 6a-hexahydropyrrolo [3, 4-d] isoxazole-4, 6-diones for advanced glycation end product formation …

A Kaur, B Singh, AS Jaggi

Index: Kaur, Anjandeep; Singh, Baldev; Jaggi, Amteshwar Singh Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 797 - 801

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Citation Number: 9

Abstract

The synthesis of some biologically interesting pyrrolo-isoxazolidine derivatives was accomplished by the 1, 3-dipolar cycloaddition reaction of substituted azomethine N-oxides 1 with substituted N-aryl maleimides 2 leading to the formation of new stereoisomeric 2, 3, 5- triaryl-4H, 2, 3, 3a, 5, 6, 6a-hexahydropyrrolo [3, 4-d] isoxazole-4, 6-dione derivatives 3 in excellent yields. The synthesized compounds have been screened for their advanced ...