Synthesis and structure-activity relationship effects on the tumor avidity of radioiodinated phospholipid ether analogues

…, MD Gross, JP Weichert, RE Counsell

Index: Pinchuk, Anatoly N.; Rampy, Mark A.; Longino, Marc A.; Skinner, R. W. Scott; Gross, Milton D.; Weichert, Jamey P.; Counsell, Raymond E. Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2155 - 2165

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Citation Number: 42

Abstract

Radioiodinated phospholipid ether analogues have shown a remarkable ability to selectively accumulate in a variety of human and animal tumors in xenograft and spontaneous tumor rodent models. It is believed that this tumor avidity arises as a consequence of metabolic differences between tumor and corresponding normal tissues. The results of this study indicate that one factor in the tumor retention of these compounds ...