Synthesis of deuterium labeled 2, 4??dipyrrolidinylpyrimidine as a chemical probe for P450 mediated oxidation of tirilazad mesylate

RT Streeper, PG Pearson, Z Zhao…

Index: Streeper, Robert T.; Pearson, Paul G.; Zhao, Zhiyang; Mizsak, Stephen A.; Vrbanac, J. James Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 7 p. 577 - 584

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Abstract

Abstract Selective deuterium labelled pyrrolidinylpyrimidine analogs were synthesized to provide a probe for the metabolite identification of Tirilazad. Synthesis of 2-[D 8]-pyrrolidinyl- 4-pyrrolidinylpyrimidine (1) and 4-[D 8]-pyrrolidinyl-2-pyrrolidinylpyrimidine (2) was accomplished by reaction of pyrrolidine (3) with 2, 4-dichloropyrimidine (4), separation of the two reaction products (5 and 6) and reaction of these products with [D 8] pyrrolidine (7).[D ...