e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Mechanistic aspects of the oxidation of 1, 3-disubstituted 6-amino-5-nitrosouracils with lead tetraacetate: the formation of pyrimido [5, 4-g] pteridinetetrone 10-oxides
M Sako, S Ohara, K Hirota, K Kano…
Index: Sako, Magoichi; Ohara, Seiji; Hirota, Kosaku; Kano, Keuji; Maki, Yoshifumi; Taylor, Edward C. Journal of Organic Chemistry, 1991 , vol. 56, # 22 p. 6302 - 6306
Results Under the reaction conditions previously utilized for the conversion of la, b to 2a, b, 6- amino-1, 3-diphenyl-5-nitrosouracil (IC) was oxidized with LTA in glacial acetic acid to give the 10-oxide 2c in 80% yield, together with a small amount of 4, 6-diphenylfurazano [3, 4-d] pyrimi-dine-5, 7 (4H, 6H)-dione (3c). Reaction of the l, &unsubstituted or 1-or 3- monosubstituted uracils ld,'le: and lf, 9 respectively, with LTA under the same conditions ...