Synthesis

Trimethylsilyl Trifluoromethanesulfonate-Promoted Cyclocondensation of β-Ketoenamides and Subsequent Nonaflation to Pyrid-2-yl and Pyrid-4-yl Nonaflates as …

P Hommes, S Berlin, HU Reissig

Index: Hommes, Paul; Berlin, Sarah; Reissig, Hans-Ulrich Synthesis (Germany), 2013 , vol. 45, # 23 p. 3288 - 3294

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Citation Number: 9

Abstract

Abstract The intramolecular condensation of β-ketoenamides to 2-and/or 4-pyridone derivatives using either KO t-Bu or trimethylsilyl trifluoromethanesulfonate/Hünig's base was investigated. Subsequent nonaflation of the cyclization products allowed a facile purification and further functionalization through Suzuki–Miyaura couplings leading to new highly substituted pyridine derivatives. The dependence of the regioselectivity of ...