Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands

…, MA Ashwell, E Trybulski, MM O'Donnell…

Index: Sabatucci, Joseph P.; Ashwell, Mark A.; Trybulski, Eugene; O'Donnell, Mary-Margaret; Moore, William J.; Harnish, Douglas C.; Chadwick, Christopher C. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 4 p. 854 - 858

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Citation Number: 6

Abstract

The transcription factor nuclear factor-κB (NF-κB) is a key component in the onset of inflammation. We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NK-κB transcriptional activity but are devoid of conventional estrogenic activity.