Tetrahedron letters

A facile zirconium (IV) chloride catalysed selective deprotection of t-butyldimethylsilyl (TBDMS) ethers

GVM Sharma, B Srinivas, PR Krishna

Index: Sharma; Srinivas; Radha Krishna, Palakodety Tetrahedron Letters, 2003 , vol. 44, # 25 p. 4689 - 4691

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Citation Number: 42

Abstract

A simple and efficient protocol for the selective deprotection of t-butyldimethylsilyl (TBDMS) ethers using 20 mol% ZrCl4 in 20–45 min and in high yields, is reported, wherein it is demonstrated that acid and base sensitive groups and allylic and benzylic groups are unaffected.