Synthesis of 1-Hydroxy-Substituted Pyrazolo [3, 4-c]-and Pyrazolo [4, 3-c] quinolines and-isoquinolines from 4-and 5-Aryl-Substituted 1-Benzyloxypyrazoles

…, P Vedsø, P Jakobsen, PO Huusfeldt…

Index: Pawlas; Vedso; Jakobsen; Huusfeldt; Begtrup Journal of Organic Chemistry, 2000 , vol. 65, # 26 p. 9001 - 9006

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Citation Number: 33

Abstract

1-Hydroxypyrazolo [3, 4-c] quinoline (22), 1-hydroxypyrazolo [4, 3-c] quinoline (21), 1- hydroxypyrazolo [3, 4-c] isoquinoline (20), and 1-hydroxypyrazolo [4, 3-c] isoquinoline (19) were prepared from 1-benzyloxypyrazole (6), establishing the pyridine B-ring in the terminal step. The pyridine ring of pyrazoloquinolines 14 and 18 was formed via cyclization of a formyl group at C-4 or C-5 and an amino group of a 2-aminophenyl substituent at C-5 or C ...