The Journal of organic chemistry

Synthesis of Acyclic Ketones by Catalytic, Bidirectional Homologation of Formaldehyde with Nonstabilized Diazoalkanes. Application of a Chiral Diazomethyl ( …

AJ Wommack, JS Kingsbury

Index: Rendina, Victor L.; Kaplan, Hilan Z.; Kingsbury, Jason S. Synthesis, 2012 , vol. 44, # 5 p. 686 - 693

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Citation Number: 15

Abstract

This work offers a catalytic approach to convergent ketone assembly based upon formal and tandem C–H insertion of diazoalkanes in the presence of limiting amounts of monomeric formaldehyde, which is easily generated as a gas by thermolysis of the inexpensive and