e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Acta Chemica Scandinavica
Cycloadditions with Alkoxynitrile Oxides. RO—CEN+—O ',(Alkyl Cyanate IV-Oxides)
HR El-Seedi, NK Jensen
Index: El-Seedi, Hesham R.; Jensen, Henrik M.; Kure, Niels; Thomsen, Ib; Torssell, Kurt B. G. Acta Chemica Scandinavica, 1993 , vol. 47, # 10 p. 1004 - 1011
Alkyl formhydroximates have been synthesized by reacting alkyl orthoesters with hydrogen sulfide followed by treatment of the alkyl thioformate formed with hydroxylamine. Chlorination of alkyl formhydroximates with N-chlorosuccinimide gives alkyl chloroformhydroximates and dehydrochlorination with base generated alkoxynitrile oxides (alkyl cyanate N-oxides), which efficiently undergo cycloaddition to olefins or acetylenes to ...