Synthesis, structure-activity relationships, and the effect of polyethylene glycol on inhibitors of phosphatidylinositol-specific phospholipase C from Bacillus cereus

…, MP Smith, TK Vinod, WL Lau, JFW Keana…

Index: Ryan, Margret; Smith, Miles P.; Vinod, Thottumkara K.; Lau, Wai Leung; Keana, John F. W.; Griffith, O. Hayes Journal of Medicinal Chemistry, 1996 , vol. 39, # 22 p. 4366 - 4376

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Citation Number: 30

Abstract

Substrate analog inhibitors of Bacillus cereus phosphatidylinositol-specific phospholipase C (PI-PLC) were synthesized and screened for their suitability to map the active site region of the enzyme by protein crystallography. Analogs of the natural substrate phosphatidylinositol (PI) were designed to examine the importance of the lipid portion and the inositol phosphate head group for binding to the enzyme. The synthetic compounds contained pentyl, hexyl, ...