The Reaction of Peroxynitrite with Organic Molecules Bearing a Biologically Important Functionality. The Multiplicity of Reaction Modes as Exemplified by …

N Nonoyama, H Oshima, C Shoda…

Index: Nonoyama, Nobuaki; Oshima, Hiroshi; Shoda, Chizuru; Suzuki, Hitomi Bulletin of the Chemical Society of Japan, 2001 , vol. 74, # 12 p. 2385 - 2395

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Citation Number: 16

Abstract

The reactions of peroxynitrite with a variety of organic molecules which include a biologically important functionality have been examined to construct a simple model for the peroxynitrite- induced in vivo transformations as well as a chemical probe for the active species involved therein. Phenols were found to undergo hydroxylation, nitration, oxidative dimerization, and oxidation to cyclohexadienones and quinones. The ring nitration of catechol was ...