e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis and biological activity of 6-ylidenethiazolidino [3, 2-c]-1, 2, 4-triazol-5-ones
EG Knysh, IA Mazur, BS Zimenkovskii…
Index: Knysh, E. G.; Mazur, I. A.; Zimenkovskii, B. S.; Smets, V. R.; Dunaev, V V.; Steblyuk, P. N. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 11 p. 765 - 767 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 11 p. 1324 - 1327
Thiazolidino ring closing can occur along edge" b" or along edge" e" of 1, 2, 4-thiazole to give 6-ylidenethiazolidino [3, 2-b]-, 6-ytidenethiazolidino [3, 2-e]-l, 2, 3-triazol-5-ones, or mixtures of the two. Thin-layer chromatography showed that after purification, the end products
![2-[(5-phenyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetic acid Structure](https://image.chemsrc.com/caspic/409/58755-01-4.png)
![(6E)-6-benzylidene-3-phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-5-one Structure](https://image.chemsrc.com/caspic/212/95356-81-3.png)
![(6E)-6-[(4-fluorophenyl)methylidene]-3-phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-5-one Structure](https://image.chemsrc.com/caspic/174/95356-82-4.png)
![(6E)-6-[(4-chlorophenyl)methylidene]-3-phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-5-one Structure](https://image.chemsrc.com/caspic/136/95356-83-5.png)