Optimal Lipophilicity of Sulfonium p-Toluenesulfonate as Anti-allergic Drug

Y Tada, I Yamawaki, S Ueda, H Matsumoto…

Index: Tada, Yukio; Yamawaki, Ichiro; Ueda, Shuichi; Matsumoto, Hiroshi; Matsuura, Naosuke; Yasumoto, Mitsugi; Koda, Akihide; Hori, Mikio Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3330 - 3336

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Abstract

Abstract In the development of the anti-allergic drug Suplatast Tosilate (IPD-1151T) we have reported the QSAR analysis using only the calculated π values, because the few logK values of sulfonium compounds had been measured till then. In this study, we measured the logKTLC value of sulfonium compounds by using octylsililated silicagel plate (Merck HPTLC RP-8 F254S). The logKTLC values of the optimized compounds 52 and 67 (Suplatast ...