Tetrahedron letters

Stereoelectronic control in the base catalyzed hydrolysis of five-membered ring cyclic phosphonamidates

JC Yang, DG Gorenstein

Index: Yang, Ji-Charng; Gorenstein, David G. Tetrahedron Letters, 1984 , vol. 25, # 41 p. 4627 - 4630

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Citation Number: 11

Abstract

Abstract The base catalyzed hydrolysis of 2-phenyl-2-oxo-3-(2, 6-dimethylphenyl)-1, 3, 2- oxazaphospholidine, 6, and 2-phenyl-2-oxo-3-(2, 6-diisopropylphenyl)-1, 3, 2- oxazaphospholidine, 7, yields ring opened products involving 95% and 100% PO cleavage, respectively.