Organic letters

Overcoming the Limitations of the Morita− Baylis− Hillman Reaction: A Rapid and General Synthesis of α-Alkenyl-β′-hydroxy Thioesters

E Tarsis, A Gromova, D Lim, G Zhou, DM Coltart

Index: Zhou, Guoqiang; Yost, Julianne M.; Sauer, Scott J.; Coltart, Don M. Organic Letters, 2007 , vol. 9, # 22 p. 4663 - 4665

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Citation Number: 21

Abstract

Acryloyl chlorides, aldehydes, and PhSLi undergo a direct aldol cascade sequence in the presence of MgBr2· OEt2 via in situ derived thioester enolates, which is followed by oxidative elimination to give α-alkenyl-β′-hydroxy thioesters. Overall, the procedure is