With the growing success of clinical programs and potential market demand for oligonucleotide-based drugs, it is important that all raw materials for synthesis of these drugs are easily accessible at affordable cost [1]1. Sanghvi , YS , Andrade , M. , Deshmukh , RR , Holmberg , L. , Scozzari , AN and Cole , DL 1999. Manual of Antisense Methodology Edited by: Hartmann , G. and Endres , S. 3–23. Kluwer Academic Publishers. ... View all references. For the ...