Study of the conversion products of thiophosphamide in aqueous solution by thin layer chromatography and mass spectrometry

TL Pyatigorskaya, OY Zhilkova, VS Shelkovskii…

Index: Pyatigorskaya, T. L.; Zhilkova, O. Yu.; Shelkovskii, V. S.; Kosevich, M. V.; Grizodub, A. I.; et al. Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 10 p. 718 - 723 Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 10 p. 1235 - 1241

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Citation Number: 6

Abstract

RESULTS Thin Layer Chromatography. Initial samples of thioTEPA dissolved in water gave a series of spots on the chromatogram (Fig. ib) the Rf values of which are given in Table l. These same spots with the exception of spot 5 were present on chromatograms of a sample of thioTEPA dissolved in methanol or chloroform (Fig, la) and also appeared on repeated application of substance isolated from a plate in the region of spot 4 corresponding to ...