Manzamine C (1) has been synthesized from silyloxyscetylene (3) along the line: 4→ 5→ 8→ 18→ 1. The overall yields is 21%. Thr β-carboline segment (11) was obtained by the Bischler-Napieralski reaction of 14 followed by dehydregenation. By the similar procedure, the trans isomer 2 and dihydromanzamine C (21) have been synthesized.
