The main procedure for the synthesis of N-and C-adamantyl-containing pyrazoles is based on acidcatalyzed adamantylation of pyrazoles with various functional derivatives of adamantane [1–6]. However, this method ensures fairly poor yields of the target products and requires strongly acidic medium. A promising method for the preparation of N- adamantylsubstituted pyrazoles involves as initial compound strained [3.3. 1] propellane, ...
[Notario, R.; Herreros, M.; Hammadi, A. El; Homan, H.; Abboud, J.-L. M.; et al. Journal of Physical Organic Chemistry, 1994 , vol. 7, # 12 p. 657 - 662]
