Organic letters

Highly Functionalized Benzene Syntheses by Directed Mono or Multiple Magnesiations with TMPMgCl⊙ LiCl

W Lin, O Baron, P Knochel

Index: Lin, Wenwei; Baron, Oliver; Knochel, Paul Organic Letters, 2006 , vol. 8, # 24 p. 5673 - 5676

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Citation Number: 129

Abstract

The direct magnesiation of highly functionalized aromatics bearing an ester, a nitrile, or a ketone can be readily performed by using an OBoc as a directing group and TMPMgCl⊙ LiCl as a base. It allows, for example, the preparation of a meta-magnesiated benzophenone in> 95%. After quenching, highly functionalized and substituted benzenes are obtained.