The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME properties

JE Imbriglio, D DiRocco, R Bodner, S Raghavan…

Index: Imbriglio, Jason E.; Dirocco, Daniel; Bodner, Rena; Raghavan, Subharekha; Chen, Weichun; Marley, Daria; Esser, Craig; Holt, Tom G.; Wolff, Michael S.; Taggart, Andrew K.P.; Waters, M. Gerard; Tata, James R.; Colletti, Steven L. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 9 p. 2721 - 2724

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Citation Number: 9

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Amino-anthranilic acid derivatives have been identified as a new class of low serum shifted, high affinity full agonists of the human orphan G-protein-coupled receptor GPR109a with improved ADME properties. ... Amino-anthranilic acid derivatives have been identified as a new ...