The Journal of Organic Chemistry

Preparations of Secondary Amines and. beta.-Amino Esters via Additions of Grignard and Reformatsky Reagents to Imines and by One-Pot Reactions of Primary …

AR Katritzky, Q Hong, Z Yang

Index: Katritzky, Alan R.; Hong, Quingmei; Yang, Zhijun Journal of Organic Chemistry, 1995 , vol. 60, # 11 p. 3405 - 3408

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Citation Number: 20

Abstract

Additions of Grignard and Reformatsky reagents to imines in the presence of 1- (trimethylsily1)-benzotriazole afforded in good yields the corresponding secondary amines and, &amino esters. The procedure is general as imines containing hydrogens a to both carbon and nitrogen can be employed. Extensions of this method to include imines containing other Lewis basic centers, eg, those derived from furan-, thiophene-, indole-, ...