Design, synthesis, and evaluations of substituted 3-[(3-or 4-carboxyethylpyrrol-2-yl) methylidenyl] indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor …

…, A Rice, R Schreck, K Waltz, LK Shawver…

Index: Sun, Li; Tran, Ngoc; Liang, Congxin; Tang, Flora; Rice, Audie; Schreck, Randall; Waltz, Kara; Shawver, Laura K.; McMahon, Gerald; Tang, Cho Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5120 - 5130

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Citation Number: 256

Abstract

Receptor tyrosine kinases (RTKs) have been implicated as therapeutic targets for the treatment of human diseases including cancers, inflammatory diseases, cardiovascular diseases including arterial restenosis, and fibrotic diseases of the lung, liver, and kidney. Three classes of 3-substituted indolin-2-ones containing propionic acid functionality attached to the pyrrole ring at the C-3 position of the core have been identified as catalytic ...