Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues

…, DW Hamprecht, PJ O'Hanlon, DJ Mitchell…

Index: Jarvest, Richard L.; Armstrong, Sula A.; Berge, John M.; Brown, Pamela; Elder, John S.; Brown, Murray J.; Copley, Royston C.B.; Forrest, Andrew K.; Hamprecht, Dieter W.; O'Hanlon, Peter J.; Mitchell, Darren J.; Rittenhouse, Stephen; Witty, David R. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 3937 - 3941

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Citation Number: 38

Abstract

Potent inhibitors of bacterial methionyl tRNA synthetase (MRS) have previously been reported. Through SAR of the quinolone moiety, the right hand side pharmacophore for MRS inhibition has now been defined as an NH–C–NH functionality in the context of a bicyclic heteroaromatic system. Potent antibacterial fused-pyrimidone and fused-imidazole analogues have been obtained and enantioselective activity demonstrated. Compound 46 ...