Synthesis of 18 F-labeled phenolphthalein and naphtholphthalein

AV Kachur, AA Popov, EJ Delikatny, JS Karp…

Index: Kachur, Alexander V.; Popov, Andrey A.; Delikatny, E. James; Karp, Joel S.; Popov, Anatoliy V. Journal of Fluorine Chemistry, 2013 , vol. 151, p. 1 - 6

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Citation Number: 6

Abstract

The fluorination of phenolphthalein and naphtholphthalein was performed with diluted fluorine gas under acidic conditions. For both compounds we observed an electrophilic fluorination into ortho position to the hydroxyl group. Through the use of this reaction we synthesized and characterized mono-and difluorinated derivatives of phenolphthalein and naphtholphthalein. The compounds were also prepared in the 18F labeled form, which ...