Pharmacology & Therapeutics 2018-04-03

Double-barreled gun: Combination of PARP inhibitor with conventional chemotherapy

Yanxin Lu, Yang Liu, Ying Pang, Karel Pacak, Chunzhang Yang

Index: 10.1016/j.pharmthera.2018.03.006

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Abstract

DNA repair pathways are evolutionarily conserved molecular mechanisms that maintain the integrity of genomic DNA. In cancer therapies, the integrity and activity of DNA repair pathways predict therapy resistance and disease outcome. Members of the poly (ADP-ribose) polymerase (PARP) family initiate and organize the biologic process of DNA repair, which counteracts many types of chemotherapies. Since the first development in approximately 3 decades ago, PARP inhibitors have greatly changed the concept of cancer therapy, leading to encouraging improvements in tumor suppression and disease outcomes. Here we summaries both pre-clinical and clinical findings of PARP inhibitors applications, particularly for combination therapies.