Tetrahedron letters

Synthesis of the C8–C20 and C21–C30 segments of pectenotoxin 2

…, F Yamamoto, M Kawamura, M Kobayashi, A Okano…

Index: Fujiwara, Kenshu; Aki, Yu-ichi; Yamamoto, Fuyuki; Kawamura, Mariko; Kobayashi, Masanori; Okano, Azusa; Awakura, Daisuke; Shiga, Shunsuke; Murai, Akio; Kawai, Hidetoshi; Suzuki, Takanori Tetrahedron Letters, 2007 , vol. 48, # 26 p. 4523 - 4527

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Citation Number: 16

Abstract

In this study, we synthesized the C8–C20 and C21–C30 segments of the diarrhetic shellfish toxin pectenotoxin 2. The C8–C20 segment was assembled from a phosphonate corresponding to the C8–C15 segment (prepared from l-malic acid in 19 steps) and an aldehyde corresponding to the C16–C20 segment (synthesized from 3-methyl-3-butenol in nine steps) by a twelve-step process including the Horner–Wadsworth–Emmons reaction, ...