Synthetic analogues of durantoside I from Citharexylum spinosum L. and their cytotoxic activity
Jutamas Apisornopas, Patamawadee Silalai, Teerapich Kasemsuk, Anan Athipornchai, Uthaiwan Sirion, Kanoknetr Suksen, Pawinee Piyachaturawat, Apichart Suksamrarn, Rungnapha Saeeng
Index: 10.1016/j.bmcl.2018.03.068
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Abstract
New iridoid glycoside derivatives from durantoside I, the latter from the dried flowers and leaves of Citharexylum spinosum, were synthesized by variously modifying a sugar moiety by silylation or acetylation and/or removal of cinnamate group at C-7 position and subsequent screening for comparative cytotoxicity against several cancer cell lines. Addition of alkylsilane to durantoside I and removal of cinnamate group were most effective in improving cytotoxicity.