Theranostics 2018-02-02

Diagnosis of LVAD Thrombus using a High-Avidity Fibrin-Specific 99mTc Probe

Grace Cui, Walter J. Akers, Michael J. Scott, Michael Nassif, John S. Allen, Anne H. Schmieder, Krishna S. Paranandi, Akinobu Itoh, Dmitry D. Beyder, Samuel Achilefu, Gregory A. Ewald, Gregory M. Lanza

Index: 10.7150/thno.20271

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Abstract

Treatment of advanced heart failure with implantable LVADs is increasing, driven by profound unmet patient need despite potential serious complications: bleeding, infection, and thrombus. The experimental objective was to develop a sensitive imaging approach to assess early thrombus accumulation in LVADs under operational high flow and high shear rates.