Expeditious Assembly of a 2??Amino??4H??chromene Skeleton by Using an Enantioselective Mannich Intramolecular Ring Cyclization–Tautomerization Cascade …

…, WY Siau, Z Du, K Zhang, J Wang

Index: Ren, Qiao; Siau, Woon-Yew; Du, Zhiyun; Zhang, Kun; Wang, Jian Chemistry - A European Journal, 2011 , vol. 17, # 28 p. 7781 - 7785

Full Text: HTML

Citation Number: 60

Abstract

The concept of a “privileged medicinal scaffold” has emerged as one of the most guiding principles in the process of drug discovery.[1] The privileged scaffold commonly consists of a rigid hetero-ring system that assigns a well-defined orientation of appended functionalities for target recognition.[2] In the light of this, the accessibility of convenient methods for the diversification of privileged scaffold functionalities impacts on the success in seeking ...