Abstract Various N-protected amino acids bearing an enol ether side chain were synthesized by a new method allowing a great versatility in the introduction of both the N- protective groups and the enol ether moieties. This method deals with a Wittig-Horner condensation to afford the α, β-dehydro homoserine ethers derivatives, followed by a regio and stereo selective isomerization into β, γ-enol ethers.
