Tetrahedron: Asymmetry

Homochiral isoquinolines by lipase-catalysed resolution and their diastereoselective functionalisation

G Guanti, R Riva

Index: Guanti, Giuseppe; Riva, Renata Tetrahedron Asymmetry, 2001 , vol. 12, # 8 p. 1185 - 1200

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Citation Number: 16

Abstract

Kinetic resolution of racemic isoquinoline alcohols and acetates has been successfully accomplished using lipases as chiral catalysts. The diastereoselective functionalisation of the isoquinoline moiety through the addition of C-nucleophiles to O-protected alcohol 9a in the presence of phenyl chloroformate has been carried out and dihydroquinolyl alcohol derivatives with high diastereomeric excess have been prepared.