Inside Cover: Butylacrylate-nucleobase Conjugates as Targets for Two-step Redox Labeling of DNA with an Osmium Tetroxide Complex (Electroanalysis 2/2018)
Pavlína Havranová-Vidláková, Jan Špaček, Lada Vítová, Monika Hermanová, Jitka Dadová, Veronika Raindlová, Michal Hocek, Miroslav Fojta, Luděk Havran
Index: 10.1002/elan.201880202
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Abstract
The cover picture shows an illustration of a two-step DNA modification with the electroactive OsO4 2,2’-bipyridine complex (Os,bpy), consisting in enzymatic construction of DNA bearing butyl acrylate (BA) moieties attached to U or to 7-deaza A, followed by chemical modification of a reactive C=C double bond in the BA residue. We demonstrate modification of the BA conjugates not only in single-stranded, but also in double-stranded (ds) DNA in which modification within the nucleobase rings in is hindered. Various DNA-Os,bpy adducts can be analyzed electrochemically and distinguished by its redox potentials. For the details see the article by P. Havranová-Vidláková et al. DOI: 10.1002/elan.201700702